PERAN PENTING SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DALAM MENINGKATKAN EFEKTIFITAS EKSTRAK HERBAL DALAM PENGOBATAN DI INDONESIA: REVIEW ARTIKEL
Kata Kunci:
self-nanoemulsifying drug delivery system (SNEDDS), Extrak Herbal, FormulasiAbstrak
Indonesia merupakan negara yang dijuluki sebagai rumah herbal dunia yang mencapai 75% bahan alam terdapat di Indonesia. Namun, sebagian besar bahan alam pada saat ini mengalami kendala dalam kelarutan air, yang mengakibatkan disolusi yang tidak optimal dan penurunan bioavailabilitas. Untuk mengatasi masalah ini, berbagai teknik telah dikembangkan, pembentukan garam, pengurangan ukuran partikel, dispersi padat, formulasi berbasis lipid, dan sebagainya. Salah satu pendekatan yang semakin mendapatkan perhatian dalam memperbaiki kelarutan obat lipofilik adalah self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS adalah campuran isotropik minyak, surfaktan, dan ko-surfaktan yang membentuk nanoemulsi minyak dalam air (o/w) dengan sedikit pengadukan. Pendekatan ini menjadi semakin penting dalam upaya meningkatkan kelarutan obat dan, oleh karena itu, meningkatkan efisiensi pengiriman obat lipofilik. Penerapan metode SNEDDS kedalam formula obat herbal akan meningkatkan efektifitas dan memperbaiki sifat bioavaibilitas nya sehingga meningkatkan efisiensi dalam memanfaatkan potensi tanaman obat di Indonesia
Referensi
Ansari, M.J., Alshetaili, A., Aldayel, I.A., Alablan, F.M., Alsulays, B., Alshahrani, S., Alalaiwe, A., Ansari, M.N., Ur Rehman, N., Shakeel, F., 2020. Formulation, Characterization, In Vitro And In Vivo Evaluations Of Self-Nanoemulsifying Drug Delivery System Of Luteolin. J. Taibah Univ. Sci. 14, 1386–1401. Https://Doi.Org/10.1080/16583655.2020.1812269
Ashfaq, M., Shah, S., Rasul, A., Hanif, M., Khan, H.U., Khames, A., Abdelgawad, M.A., Ghoneim, M.M., Ali, M.Y., Abourehab, M.A.S., Maheen, S., Iqbal, O., Abbas, G., El Sisi, A.M., 2022. Enhancement Of The Solubility And Bioavailability Of Pitavastatin Through A Self-Nanoemulsifying Drug Delivery System (SNEDDS). Pharmaceutics 14, 482. Https://Doi.Org/10.3390/Pharmaceutics14030482
Buya, A.B., Beloqui, A., Memvanga, P.B., Préat, V., 2020. Self-Nano-Emulsifying Drug-Delivery Systems: From The Development To The Current Applications And Challenges In Oral Drug Delivery. Pharmaceutics 12, 1194. Https://Doi.Org/10.3390/Pharmaceutics12121194
Daraee, H., Eatemadi, A., Abbasi, E., Fekri Aval, S., Kouhi, M., Akbarzadeh, A., 2016. Application Of Gold Nanoparticles In Biomedical And Drug Delivery. Artif. Cells Nanomedicine Biotechnol. 44, 410–422. Https://Doi.Org/10.3109/21691401.2014.955107
Ding, W., Hou, X., Cong, S., Zhang, Y., Chen, M., Lei, J., Meng, Y., Li, X., Li, G., 2016. Co-Delivery Of Honokiol, A Constituent Of Magnolia Species, In A Self-Microemulsifying Drug Delivery System For Improved Oral Transport Of Lipophilic Sirolimus. Drug Deliv. 23, 2513–2523. Https://Doi.Org/10.3109/10717544.2015.1020119
Fitria, A., Hanifah, S., Chabib, L., Uno, A.M., Munawwarah, H., Atsil, N., Pohara, H.A., Weuanggi, D.A., Syukri, Y., 2021. Design And Characterization Of Propolis Extract Loaded Self-Nano Emulsifying Drug Delivery System As Immunostimulant. Saudi Pharm. J. 29, 625–634. Https://Doi.Org/10.1016/J.Jsps.2021.04.024
Gonibala, A.P., Mappa, M.R., Kuna, M.R., 2022. Edukasi Pengolahan Bahan Alam Sebagai Alternatif Pengobatan Tradisional Di Desa Muntoi Kabupaten Bolaang Mongondow.
Hayati, F., Chabib, L., Sekarraras, F.D., Faizah, W.S., 2021. Antihyperglycemic Activity Of Centella Asiatica (L.) Urb. Leaf Ethanol Extract SNEDDS In Zebrafish ( Danio Rerio ). Open Chem. 19, 184–188. Https://Doi.Org/10.1515/Chem-2021-0200
Hussain, M.D., Mohsin, K., Alamari, R., Ahmad, A., Raish, M., Alanzi, F., 2016. Development Of Self-Nanoemulsifying Drug Delivery Systems For The Enhancement Of Solubility And Oral Bioavailability Of Fenofibrate, A Poorly Water-Soluble Drug. Int. J. Nanomedicine 2829. Https://Doi.Org/10.2147/IJN.S104187
Joshi, R.P., Negi, G., Kumar, A., Pawar, Y.B., Munjal, B., Bansal, A.K., Sharma, S.S., 2013. SNEDDS Curcumin Formulation Leads To Enhanced Protection From Pain And Functional Deficits Associated With Diabetic Neuropathy: An Insight Into Its Mechanism For Neuroprotection. Nanomedicine Nanotechnol. Biol. Med. 9, 776–785. Https://Doi.Org/10.1016/J.Nano.2013.01.001
Kamble, R.N., Mehta, P.P., Kumar, A., 2016. Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro And In Vivo Evaluation. AAPS Pharmscitech 17, 1240–1247. Https://Doi.Org/10.1208/S12249-015-0446-2
Kassem, A.A., Abd El-Alim, S.H., Salman, A.M., Mohammed, M.A., Hassan, N.S., El-Gengaihi, S.E., 2020. Improved Hepatoprotective Activity Of Beta Vulgaris L. Leaf Extract Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS): In Vitro And In Vivo Evaluation. Drug Dev. Ind. Pharm. 46, 1589–1603. Https://Doi.Org/10.1080/03639045.2020.1811303
Kazi, M., Alhajri, A., Alshehri, S.M., Elzayat, E.M., Al Meanazel, O.T., Shakeel, F., Noman, O., Altamimi, M.A., Alanazi, F.K., 2020a. Enhancing Oral Bioavailability Of Apigenin Using A Bioactive Self-Nanoemulsifying Drug Delivery System (Bio-SNEDDS): In Vitro, In Vivo And Stability Evaluations. Pharmaceutics 12, 749. Https://Doi.Org/10.3390/Pharmaceutics12080749
Kazi, M., Shahba, A.A., Alrashoud, S., Alwadei, M., Sherif, A.Y., Alanazi, F.K., 2020b. Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) For Combined Oral Delivery Of Curcumin And Piperine. Molecules 25, 1703. Https://Doi.Org/10.3390/Molecules25071703
Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I.S., Müllertz, A., Fatouros, D.G., 2020. In Vitro Evaluation Of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (Rtils) For The Oral Delivery Of Amphotericin B. Pharmaceutics 12, 699. Https://Doi.Org/10.3390/Pharmaceutics12080699
Mehanna, M.M., Mneimneh, A.T., 2020. Formulation And Applications Of Lipid-Based Nanovehicles: Spotlight On Self-Emulsifying Systems. Adv. Pharm. Bull. 11, 56–67. Https://Doi.Org/10.34172/Apb.2021.006
Mitchell, M.J., Billingsley, M.M., Haley, R.M., Wechsler, M.E., Peppas, N.A., Langer, R., 2021. Engineering Precision Nanoparticles For Drug Delivery. Nat. Rev. Drug Discov. 20, 101–124. Https://Doi.Org/10.1038/S41573-020-0090-8
Morakul, B., 2020. Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Advancement Technology For Oral Drug Delivery. Pharm. Sci. Asia 47, 205–220. Https://Doi.Org/10.29090/Psa.2020.03.019.0121
Nazlı, H., Mesut, B., Özsoy, Y., 2021. In Vitro Evaluation Of A Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) Of Aprepitant For Enhanced Solubility. Pharmaceuticals 14, 1089. Https://Doi.Org/10.3390/Ph14111089
Nugroho, B.H., Citrariana, S., Sari, I.N., Oktari, R.N., Munawwarah, M., 2017. Formulasi Dan Evaluasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Ekstrak Daun Pepaya (Carica Papaya L.) Sebagai Analgesik. J. Ilm. Farm. 13, 77–85. Https://Doi.Org/10.20885/Jif.Vol13.Iss2.Art5
Prihapsara, F., Artanti, A.N., Harini, M., Widiyani, T., Nazilla, S.Z., N.D. Formulating Self-Microemulsifying Drug Delivery Systems From Bay Leaves (Eugenia Polyantha Wight) With Virgin Coconut Oil And Its Anti- Diabetic Activity.
Singh, A.P., Khatik, G.L., Mishra, V., Khurana, N., Sharma, N., Vyas, M., 2019. FORMULATION DEVELOPMENT AND IN VITRO ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF ERIOBOTRYA JAPONICA BASED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM. Int. J. Appl. Pharm. 313–319. Https://Doi.Org/10.22159/Ijap.2019v11i4.33006
Suliasih, B.A., Mun’im, A., 2022. Review: Potensi Dan Masalah Dalam Pengembangan Kemandirian Bahan Baku Obat Tradisional Di Indonesia. Chem Mater.
Sumirtapura, Y.C., Pamudji, J.S., Mudhakir, D., Suhery, W.N., 2020. Development And Characterization Of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Formulation For Enhancing Dissolution Of Fenofibric Acid. J. Res. Pharm. 24, 738–747. Https://Doi.Org/10.35333/Jrp.2020.227
Syukri, Y., Fitriani, H., Pandapotan, H., Nugroho, B.H., 2019. Formulation, Characterization And Stability Of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Indones. J. Pharm. 30, 105. Https://Doi.Org/10.14499/Indonesianjpharm30iss2pp105-113
Zafar, A., Imam, S.S., Alruwaili, N.K., Alsaidan, O.A., Elkomy, M.H., Ghoneim, M.M., Alshehri, S., Ali, A.M.A., Alharbi, K.S., Yasir, M., Noorulla, K.M., Alzarea, S.I., Alanazi, A.S., 2021. Development Of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, And In-Vivo Evaluation. Nanomaterials 11, 2920. Https://Doi.Org/10.3390/Nano11112920
Zhao, Z., Cui, X., Ma, X., Wang, Z., 2020. Preparation, Characterization, And Evaluation Of Antioxidant Activity And Bioavailability Of A Self-Nanoemulsifying Drug Delivery System (SNEDDS) For Buckwheat Flavonoids. Acta Biochim. Biophys. Sin. 52, 1265–1274. Https://Doi.Org/10.1093/Abbs/Gmaa124
Ashfaq, M., Shah, S., Rasul, A., Hanif, M., Khan, H.U., Khames, A., Abdelgawad, M.A., Ghoneim, M.M., Ali, M.Y., Abourehab, M.A.S., Maheen, S., Iqbal, O., Abbas, G., El Sisi, A.M., 2022. Enhancement Of The Solubility And Bioavailability Of Pitavastatin Through A Self-Nanoemulsifying Drug Delivery System (SNEDDS). Pharmaceutics 14, 482. Https://Doi.Org/10.3390/Pharmaceutics14030482
Buya, A.B., Beloqui, A., Memvanga, P.B., Préat, V., 2020. Self-Nano-Emulsifying Drug-Delivery Systems: From The Development To The Current Applications And Challenges In Oral Drug Delivery. Pharmaceutics 12, 1194. Https://Doi.Org/10.3390/Pharmaceutics12121194
Daraee, H., Eatemadi, A., Abbasi, E., Fekri Aval, S., Kouhi, M., Akbarzadeh, A., 2016. Application Of Gold Nanoparticles In Biomedical And Drug Delivery. Artif. Cells Nanomedicine Biotechnol. 44, 410–422. Https://Doi.Org/10.3109/21691401.2014.955107
Ding, W., Hou, X., Cong, S., Zhang, Y., Chen, M., Lei, J., Meng, Y., Li, X., Li, G., 2016. Co-Delivery Of Honokiol, A Constituent Of Magnolia Species, In A Self-Microemulsifying Drug Delivery System For Improved Oral Transport Of Lipophilic Sirolimus. Drug Deliv. 23, 2513–2523. Https://Doi.Org/10.3109/10717544.2015.1020119
Fitria, A., Hanifah, S., Chabib, L., Uno, A.M., Munawwarah, H., Atsil, N., Pohara, H.A., Weuanggi, D.A., Syukri, Y., 2021. Design And Characterization Of Propolis Extract Loaded Self-Nano Emulsifying Drug Delivery System As Immunostimulant. Saudi Pharm. J. 29, 625–634. Https://Doi.Org/10.1016/J.Jsps.2021.04.024
Gonibala, A.P., Mappa, M.R., Kuna, M.R., 2022. Edukasi Pengolahan Bahan Alam Sebagai Alternatif Pengobatan Tradisional Di Desa Muntoi Kabupaten Bolaang Mongondow.
Hayati, F., Chabib, L., Sekarraras, F.D., Faizah, W.S., 2021. Antihyperglycemic Activity Of Centella Asiatica (L.) Urb. Leaf Ethanol Extract SNEDDS In Zebrafish ( Danio Rerio ). Open Chem. 19, 184–188. Https://Doi.Org/10.1515/Chem-2021-0200
Hussain, M.D., Mohsin, K., Alamari, R., Ahmad, A., Raish, M., Alanzi, F., 2016. Development Of Self-Nanoemulsifying Drug Delivery Systems For The Enhancement Of Solubility And Oral Bioavailability Of Fenofibrate, A Poorly Water-Soluble Drug. Int. J. Nanomedicine 2829. Https://Doi.Org/10.2147/IJN.S104187
Joshi, R.P., Negi, G., Kumar, A., Pawar, Y.B., Munjal, B., Bansal, A.K., Sharma, S.S., 2013. SNEDDS Curcumin Formulation Leads To Enhanced Protection From Pain And Functional Deficits Associated With Diabetic Neuropathy: An Insight Into Its Mechanism For Neuroprotection. Nanomedicine Nanotechnol. Biol. Med. 9, 776–785. Https://Doi.Org/10.1016/J.Nano.2013.01.001
Kamble, R.N., Mehta, P.P., Kumar, A., 2016. Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro And In Vivo Evaluation. AAPS Pharmscitech 17, 1240–1247. Https://Doi.Org/10.1208/S12249-015-0446-2
Kassem, A.A., Abd El-Alim, S.H., Salman, A.M., Mohammed, M.A., Hassan, N.S., El-Gengaihi, S.E., 2020. Improved Hepatoprotective Activity Of Beta Vulgaris L. Leaf Extract Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS): In Vitro And In Vivo Evaluation. Drug Dev. Ind. Pharm. 46, 1589–1603. Https://Doi.Org/10.1080/03639045.2020.1811303
Kazi, M., Alhajri, A., Alshehri, S.M., Elzayat, E.M., Al Meanazel, O.T., Shakeel, F., Noman, O., Altamimi, M.A., Alanazi, F.K., 2020a. Enhancing Oral Bioavailability Of Apigenin Using A Bioactive Self-Nanoemulsifying Drug Delivery System (Bio-SNEDDS): In Vitro, In Vivo And Stability Evaluations. Pharmaceutics 12, 749. Https://Doi.Org/10.3390/Pharmaceutics12080749
Kazi, M., Shahba, A.A., Alrashoud, S., Alwadei, M., Sherif, A.Y., Alanazi, F.K., 2020b. Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) For Combined Oral Delivery Of Curcumin And Piperine. Molecules 25, 1703. Https://Doi.Org/10.3390/Molecules25071703
Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I.S., Müllertz, A., Fatouros, D.G., 2020. In Vitro Evaluation Of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (Rtils) For The Oral Delivery Of Amphotericin B. Pharmaceutics 12, 699. Https://Doi.Org/10.3390/Pharmaceutics12080699
Mehanna, M.M., Mneimneh, A.T., 2020. Formulation And Applications Of Lipid-Based Nanovehicles: Spotlight On Self-Emulsifying Systems. Adv. Pharm. Bull. 11, 56–67. Https://Doi.Org/10.34172/Apb.2021.006
Mitchell, M.J., Billingsley, M.M., Haley, R.M., Wechsler, M.E., Peppas, N.A., Langer, R., 2021. Engineering Precision Nanoparticles For Drug Delivery. Nat. Rev. Drug Discov. 20, 101–124. Https://Doi.Org/10.1038/S41573-020-0090-8
Morakul, B., 2020. Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Advancement Technology For Oral Drug Delivery. Pharm. Sci. Asia 47, 205–220. Https://Doi.Org/10.29090/Psa.2020.03.019.0121
Nazlı, H., Mesut, B., Özsoy, Y., 2021. In Vitro Evaluation Of A Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) Of Aprepitant For Enhanced Solubility. Pharmaceuticals 14, 1089. Https://Doi.Org/10.3390/Ph14111089
Nugroho, B.H., Citrariana, S., Sari, I.N., Oktari, R.N., Munawwarah, M., 2017. Formulasi Dan Evaluasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Ekstrak Daun Pepaya (Carica Papaya L.) Sebagai Analgesik. J. Ilm. Farm. 13, 77–85. Https://Doi.Org/10.20885/Jif.Vol13.Iss2.Art5
Prihapsara, F., Artanti, A.N., Harini, M., Widiyani, T., Nazilla, S.Z., N.D. Formulating Self-Microemulsifying Drug Delivery Systems From Bay Leaves (Eugenia Polyantha Wight) With Virgin Coconut Oil And Its Anti- Diabetic Activity.
Singh, A.P., Khatik, G.L., Mishra, V., Khurana, N., Sharma, N., Vyas, M., 2019. FORMULATION DEVELOPMENT AND IN VITRO ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF ERIOBOTRYA JAPONICA BASED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM. Int. J. Appl. Pharm. 313–319. Https://Doi.Org/10.22159/Ijap.2019v11i4.33006
Suliasih, B.A., Mun’im, A., 2022. Review: Potensi Dan Masalah Dalam Pengembangan Kemandirian Bahan Baku Obat Tradisional Di Indonesia. Chem Mater.
Sumirtapura, Y.C., Pamudji, J.S., Mudhakir, D., Suhery, W.N., 2020. Development And Characterization Of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Formulation For Enhancing Dissolution Of Fenofibric Acid. J. Res. Pharm. 24, 738–747. Https://Doi.Org/10.35333/Jrp.2020.227
Syukri, Y., Fitriani, H., Pandapotan, H., Nugroho, B.H., 2019. Formulation, Characterization And Stability Of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Indones. J. Pharm. 30, 105. Https://Doi.Org/10.14499/Indonesianjpharm30iss2pp105-113
Zafar, A., Imam, S.S., Alruwaili, N.K., Alsaidan, O.A., Elkomy, M.H., Ghoneim, M.M., Alshehri, S., Ali, A.M.A., Alharbi, K.S., Yasir, M., Noorulla, K.M., Alzarea, S.I., Alanazi, A.S., 2021. Development Of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, And In-Vivo Evaluation. Nanomaterials 11, 2920. Https://Doi.Org/10.3390/Nano11112920
Zhao, Z., Cui, X., Ma, X., Wang, Z., 2020. Preparation, Characterization, And Evaluation Of Antioxidant Activity And Bioavailability Of A Self-Nanoemulsifying Drug Delivery System (SNEDDS) For Buckwheat Flavonoids. Acta Biochim. Biophys. Sin. 52, 1265–1274. Https://Doi.Org/10.1093/Abbs/Gmaa124
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PERAN PENTING SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DALAM MENINGKATKAN EFEKTIFITAS EKSTRAK HERBAL DALAM PENGOBATAN DI INDONESIA: REVIEW ARTIKEL. (2025). Jurnal Farmasi IKIFA, 4(1), 23-37. https://epik.ikifa.ac.id/jfi/article/view/256
