PERAN PENTING SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DALAM MENINGKATKAN EFEKTIFITAS EKSTRAK HERBAL DALAM PENGOBATAN DI INDONESIA: REVIEW ARTIKEL
Keywords:
self-nanoemulsifying drug delivery system (SNEDDS), Herbal Extract, FormulationAbstract
Indonesia is a country dubbed as the world's herbal home, reaching 75% of natural ingredients found in Indonesia. However, most natural ingredients currently experience constraints in water solubility, resulting in suboptimal dissolution and decreased bioavailability. To overcome this problem, various techniques have been developed, salt formation, particle size reduction, solid dispersion, lipid-based formulations, and so on. One approach that is increasingly gaining attention in improving the solubility of lipophilic drugs is the self-nanoemulsifying drug delivery system (SNEDDS). SNEDDS is an isotropic mixture of oil, surfactants, and co-surfactants that forms oil-in-water (o/w) nanoemulsions with minimal stirring. This approach is becoming increasingly important in efforts to improve drug solubility and, therefore, increase the efficiency of lipophilic drug delivery. The application of the SNEDDS method to herbal medicine formulas will increase effectiveness and improve their bioavailability properties, thereby increasing efficiency in utilizing the potential of medicinal plants in Indonesia.
References
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Zhao, Z., Cui, X., Ma, X., Wang, Z., 2020. Preparation, Characterization, And Evaluation Of Antioxidant Activity And Bioavailability Of A Self-Nanoemulsifying Drug Delivery System (SNEDDS) For Buckwheat Flavonoids. Acta Biochim. Biophys. Sin. 52, 1265–1274. Https://Doi.Org/10.1093/Abbs/Gmaa124
Ashfaq, M., Shah, S., Rasul, A., Hanif, M., Khan, H.U., Khames, A., Abdelgawad, M.A., Ghoneim, M.M., Ali, M.Y., Abourehab, M.A.S., Maheen, S., Iqbal, O., Abbas, G., El Sisi, A.M., 2022. Enhancement Of The Solubility And Bioavailability Of Pitavastatin Through A Self-Nanoemulsifying Drug Delivery System (SNEDDS). Pharmaceutics 14, 482. Https://Doi.Org/10.3390/Pharmaceutics14030482
Buya, A.B., Beloqui, A., Memvanga, P.B., Préat, V., 2020. Self-Nano-Emulsifying Drug-Delivery Systems: From The Development To The Current Applications And Challenges In Oral Drug Delivery. Pharmaceutics 12, 1194. Https://Doi.Org/10.3390/Pharmaceutics12121194
Daraee, H., Eatemadi, A., Abbasi, E., Fekri Aval, S., Kouhi, M., Akbarzadeh, A., 2016. Application Of Gold Nanoparticles In Biomedical And Drug Delivery. Artif. Cells Nanomedicine Biotechnol. 44, 410–422. Https://Doi.Org/10.3109/21691401.2014.955107
Ding, W., Hou, X., Cong, S., Zhang, Y., Chen, M., Lei, J., Meng, Y., Li, X., Li, G., 2016. Co-Delivery Of Honokiol, A Constituent Of Magnolia Species, In A Self-Microemulsifying Drug Delivery System For Improved Oral Transport Of Lipophilic Sirolimus. Drug Deliv. 23, 2513–2523. Https://Doi.Org/10.3109/10717544.2015.1020119
Fitria, A., Hanifah, S., Chabib, L., Uno, A.M., Munawwarah, H., Atsil, N., Pohara, H.A., Weuanggi, D.A., Syukri, Y., 2021. Design And Characterization Of Propolis Extract Loaded Self-Nano Emulsifying Drug Delivery System As Immunostimulant. Saudi Pharm. J. 29, 625–634. Https://Doi.Org/10.1016/J.Jsps.2021.04.024
Gonibala, A.P., Mappa, M.R., Kuna, M.R., 2022. Edukasi Pengolahan Bahan Alam Sebagai Alternatif Pengobatan Tradisional Di Desa Muntoi Kabupaten Bolaang Mongondow.
Hayati, F., Chabib, L., Sekarraras, F.D., Faizah, W.S., 2021. Antihyperglycemic Activity Of Centella Asiatica (L.) Urb. Leaf Ethanol Extract SNEDDS In Zebrafish ( Danio Rerio ). Open Chem. 19, 184–188. Https://Doi.Org/10.1515/Chem-2021-0200
Hussain, M.D., Mohsin, K., Alamari, R., Ahmad, A., Raish, M., Alanzi, F., 2016. Development Of Self-Nanoemulsifying Drug Delivery Systems For The Enhancement Of Solubility And Oral Bioavailability Of Fenofibrate, A Poorly Water-Soluble Drug. Int. J. Nanomedicine 2829. Https://Doi.Org/10.2147/IJN.S104187
Joshi, R.P., Negi, G., Kumar, A., Pawar, Y.B., Munjal, B., Bansal, A.K., Sharma, S.S., 2013. SNEDDS Curcumin Formulation Leads To Enhanced Protection From Pain And Functional Deficits Associated With Diabetic Neuropathy: An Insight Into Its Mechanism For Neuroprotection. Nanomedicine Nanotechnol. Biol. Med. 9, 776–785. Https://Doi.Org/10.1016/J.Nano.2013.01.001
Kamble, R.N., Mehta, P.P., Kumar, A., 2016. Efavirenz Self-Nano-Emulsifying Drug Delivery System: In Vitro And In Vivo Evaluation. AAPS Pharmscitech 17, 1240–1247. Https://Doi.Org/10.1208/S12249-015-0446-2
Kassem, A.A., Abd El-Alim, S.H., Salman, A.M., Mohammed, M.A., Hassan, N.S., El-Gengaihi, S.E., 2020. Improved Hepatoprotective Activity Of Beta Vulgaris L. Leaf Extract Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS): In Vitro And In Vivo Evaluation. Drug Dev. Ind. Pharm. 46, 1589–1603. Https://Doi.Org/10.1080/03639045.2020.1811303
Kazi, M., Alhajri, A., Alshehri, S.M., Elzayat, E.M., Al Meanazel, O.T., Shakeel, F., Noman, O., Altamimi, M.A., Alanazi, F.K., 2020a. Enhancing Oral Bioavailability Of Apigenin Using A Bioactive Self-Nanoemulsifying Drug Delivery System (Bio-SNEDDS): In Vitro, In Vivo And Stability Evaluations. Pharmaceutics 12, 749. Https://Doi.Org/10.3390/Pharmaceutics12080749
Kazi, M., Shahba, A.A., Alrashoud, S., Alwadei, M., Sherif, A.Y., Alanazi, F.K., 2020b. Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) For Combined Oral Delivery Of Curcumin And Piperine. Molecules 25, 1703. Https://Doi.Org/10.3390/Molecules25071703
Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I.S., Müllertz, A., Fatouros, D.G., 2020. In Vitro Evaluation Of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (Rtils) For The Oral Delivery Of Amphotericin B. Pharmaceutics 12, 699. Https://Doi.Org/10.3390/Pharmaceutics12080699
Mehanna, M.M., Mneimneh, A.T., 2020. Formulation And Applications Of Lipid-Based Nanovehicles: Spotlight On Self-Emulsifying Systems. Adv. Pharm. Bull. 11, 56–67. Https://Doi.Org/10.34172/Apb.2021.006
Mitchell, M.J., Billingsley, M.M., Haley, R.M., Wechsler, M.E., Peppas, N.A., Langer, R., 2021. Engineering Precision Nanoparticles For Drug Delivery. Nat. Rev. Drug Discov. 20, 101–124. Https://Doi.Org/10.1038/S41573-020-0090-8
Morakul, B., 2020. Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Advancement Technology For Oral Drug Delivery. Pharm. Sci. Asia 47, 205–220. Https://Doi.Org/10.29090/Psa.2020.03.019.0121
Nazlı, H., Mesut, B., Özsoy, Y., 2021. In Vitro Evaluation Of A Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) Of Aprepitant For Enhanced Solubility. Pharmaceuticals 14, 1089. Https://Doi.Org/10.3390/Ph14111089
Nugroho, B.H., Citrariana, S., Sari, I.N., Oktari, R.N., Munawwarah, M., 2017. Formulasi Dan Evaluasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Ekstrak Daun Pepaya (Carica Papaya L.) Sebagai Analgesik. J. Ilm. Farm. 13, 77–85. Https://Doi.Org/10.20885/Jif.Vol13.Iss2.Art5
Prihapsara, F., Artanti, A.N., Harini, M., Widiyani, T., Nazilla, S.Z., N.D. Formulating Self-Microemulsifying Drug Delivery Systems From Bay Leaves (Eugenia Polyantha Wight) With Virgin Coconut Oil And Its Anti- Diabetic Activity.
Singh, A.P., Khatik, G.L., Mishra, V., Khurana, N., Sharma, N., Vyas, M., 2019. FORMULATION DEVELOPMENT AND IN VITRO ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF ERIOBOTRYA JAPONICA BASED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM. Int. J. Appl. Pharm. 313–319. Https://Doi.Org/10.22159/Ijap.2019v11i4.33006
Suliasih, B.A., Mun’im, A., 2022. Review: Potensi Dan Masalah Dalam Pengembangan Kemandirian Bahan Baku Obat Tradisional Di Indonesia. Chem Mater.
Sumirtapura, Y.C., Pamudji, J.S., Mudhakir, D., Suhery, W.N., 2020. Development And Characterization Of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Formulation For Enhancing Dissolution Of Fenofibric Acid. J. Res. Pharm. 24, 738–747. Https://Doi.Org/10.35333/Jrp.2020.227
Syukri, Y., Fitriani, H., Pandapotan, H., Nugroho, B.H., 2019. Formulation, Characterization And Stability Of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Indones. J. Pharm. 30, 105. Https://Doi.Org/10.14499/Indonesianjpharm30iss2pp105-113
Zafar, A., Imam, S.S., Alruwaili, N.K., Alsaidan, O.A., Elkomy, M.H., Ghoneim, M.M., Alshehri, S., Ali, A.M.A., Alharbi, K.S., Yasir, M., Noorulla, K.M., Alzarea, S.I., Alanazi, A.S., 2021. Development Of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, And In-Vivo Evaluation. Nanomaterials 11, 2920. Https://Doi.Org/10.3390/Nano11112920
Zhao, Z., Cui, X., Ma, X., Wang, Z., 2020. Preparation, Characterization, And Evaluation Of Antioxidant Activity And Bioavailability Of A Self-Nanoemulsifying Drug Delivery System (SNEDDS) For Buckwheat Flavonoids. Acta Biochim. Biophys. Sin. 52, 1265–1274. Https://Doi.Org/10.1093/Abbs/Gmaa124
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PERAN PENTING SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DALAM MENINGKATKAN EFEKTIFITAS EKSTRAK HERBAL DALAM PENGOBATAN DI INDONESIA: REVIEW ARTIKEL. (2025). Jurnal Farmasi IKIFA, 4(1), 23-37. https://epik.ikifa.ac.id/jfi/article/view/256
