EVALUATION OF ORAL ANTI-DIABETES ADVERSE DRUG REACTIONS (ADRs) BASED ON THE NARANJO ALGORITHM IN SOEWONDO PATI INSTITUTION
Keywords:
Diabetes Mellitus, Naranjo Algorithm, Type IIAbstract
Background: Diabetes mellitus (DM) is a group of chronic metabolic disorders caused by genetic factors due to reduced insulin production by the pancreas which is indicated by an increase in blood sugar levels causing chronic complications both microvascular and macrovascular due to insufficient insulin function. Objective: To evaluate ADRs. in antidiabetic patients based on the Naranjo algorithm in the Soewondo Hospital, Pati Regency. Research Methods: In this study using quantitative research where the data obtained is in the form of numbers. The type of research used is descriptive, because this research describes the phenomenon of health problems in the form of side effects from diabetes mellitus in Soewondo Hospital, Pati Regency. Results: In patients with diabetes mellitus inpatient at Soewondo Hospital Pati, the most frequent occurrence was dizziness with a percentage of 21.1%. The use of metformin in combination with 2 drugs in DM patients can cause nausea, vomiting and dizziness. it was found that the incidence rate of ADR at a score of 5-8 with a degree of probable certainty (ESO could occur) had the highest percentage (55.5%). Based on gender, there were 43 male patients (52.2%) and 47 female patients (47.7%). It can be seen that during the period January 2020 - December 2022 at the age of 30-40 years there were 20 patients with a percentage of (22.2%), aged 41-50 years there were 25 patients with a percentage of (27.7%), while the 51-60 years there were 45 patients with a percentage of (50.0%). Conclusion: Antidiabetic ADRs based on the Naranjo Algorithm in DM patients in Soewondo Pati inpatient care, the most values can be obtained between categories 5-8 which means "ESO may occur (Probable).
References
1. Achmad A. Kejadian efek samping potensial terapi obat anti diabetes pada pasien diabetes melitus berdasarkan algoritme Naranjo. Pharm J Indones. 2017;2(2):45–50.
2. Cho NH, Shaw JE, Karuranga S, Huang Y, Rocha FJD, Ohlrogge AW, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–81.
3. Handayani D. Jurnal Ilmiah Kefarmasian. 2022;7(3).
4. DiPiro JT, Wells BG, Schwinghammer TL, DiPiro CV. Pharmacotherapy handbook. 10th ed. New York: McGraw-Hill Education; 2016.
5. Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: a pathophysiologic approach. 8th ed. New York: McGraw-Hill; 2011.
6. Isnaini N, Muliyani. Studi farmakovigilans obat antidiabetes pada pasien rawat jalan diabetes melitus tipe II di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. J Ilmiah Ibnu Sina. 2018;3(2):285–93.
7. Kementerian Kesehatan Republik Indonesia. InfoDATIN: Situasi dan analisis lanjut usia. Jakarta: Kemenkes RI; 2017.
8. Lacy CF, Armstrong L, Goldman MP, Lance LL. Drug information handbook. 22nd ed. Hudson (OH): Lexi-Comp; 2014. p. 954–6
9. PERKENI. Konsensus pengendalian dan pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta: PERKENI; 2011. p. 6, 21–36
10. Gumantara MPB, Oktarlina RZ. Perbandingan monoterapi dan kombinasi terapi sulfonilurea metformin terhadap pasien diabetes melitus tipe 2. Majority. 2017;6(1):55–59
11. Putra RJS, Achmad A, Racma H. Kejadian efek samping potensial terapi obat antidiabetes pasien diabetes melitus berdasarkan algoritma Naranjo. Pharm J Indones. 2017;2(2):45–50.
12. Lubis MA, Suprianto S. Analisis cost-effectiveness penggunaan antidiabetik oral pada pasien DM tipe 2 rawat jalan peserta BPJS di RSU Haji Medan. J Dunia Farmasi. 2018;2(3):128–47.
13. Davies EC, Green CF, Mottram DR, Pirmohamed M. Adverse drug reactions in hospital in patients: a pilot study. J Clin Pharm Ther. 2006;31(4):335–41
14. Li XX, Zhuo L, Zhang Y, Yang YH, Zhang H, Zhan SY, Zhai SD. The incidence and risk factors for adverse drug reactions related to Tanreqing injection: a large population-based study in China. Front Pharmacol. 2020;10:1523
15. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356(9237):1255-1259. doi:10.1016/S0140-6736(00)02799-9
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Jurnal Farmasi IKIFA
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
