EFFECT OF PEG 6000 ON TABLET DISSOLUTION ACETOSAL IN SOLID DISPERSION SYSTEM
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Abstract
Acetosal is included in class II non-steroidal anti-inflammatory drugs according to the Biopharmaceutical Classification System (BCS) which has low solubility and high permeability. Low solubility is an obstacle in drug release so it is necessary to develop active ingredients in increasing the dissolution rate. Polyethylene glycol 6000 is a water-soluble polymer and is most widely used in solid dispersion systems. This study aims to determine the effect of the addition of PEG 6000 on the dissolution rate of acetosal in a solid dispersion system. Solid dispersion using dissolution method with variation of acetosal concentration: PEG 6000 1:0, 1:1, 1:2, 1:3, 1:4 and 1:5. The best solid dispersion dissolution is found in the 1:3 ratio with a value of 98.87%. The results of the one way ANOVA test resulted in a significance value of 0.186 (p < 0.05) which indicates that there is no significant difference in dissolution rate due to the addition of PEG 6000 to the solid dispersion system formulation. The best dispersion formula results were made tablet preparations. The physical evaluation of tablets obtained results are weight uniformity test (mg) (641.4 ± 4.05), size uniformity test (cm) (diameter 1.19 ± 0.01 and thickness 0.409 ± 0.003), friability test (%) (0.23 ± 0.20), hardness test (kg) (4.5 ± 0.3), disintegration time test (minutes) (7.06 ± 1.04) and acetosal tablets dissolved 99.87% within 30 minutes. The conclusion of this study is that the addition of PEG 6000 in the solid dispersion system of acetosal tablets can increase the dissolution rate of acetosal tablets in solid dispersion systems and improve the physical properties of acetosal tablets.
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References
Apsari, P. A., Sari, D. N. E., Kusuma, A. P., & Indrati, O. (2018). Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources. EKSAKTA: Journal of Sciences and Data Analysis, 18, 30–41. https://doi.org/10.20885/eksakta.vol18.iss1.art4
Cheiya, I., Rusli, R., & Fitriani, N. (2023). Utilization of Waste Banana Peel Starch (Musa paradisiaca) as a Binder Material for Paracetamol Granules Using Wet Granulation. Jurnal Sains Dan Kesehatan, 5, 44–49. https://doi.org/10.25026/jsk.v5i1.1606
Dominas, C., Gadkaree, S., Maxfield, A. Z., Gray, S. T., & Bergmark, R. W. (2020). Aspirin-exacerbated respiratory disease: A review. Laryngoscope Investigative Otolaryngology, 5(3), 360–367. https://doi.org/10.1002/lio2.387
Elmubarak, E. H., Osman, Z. A., & Abdelrahman, M. (2021). Formulation and Evaluation of Solid Dispersion Tablets of Furosemide Using Polyvinylpyrrolidone K-30. International Journal of Current Pharmaceutical Research, 13(2), 43–50. https://doi.org/10.22159/ijcpr.2021v13i2.41554
Engelen, A. (2018). Karakteristik Kimia Pada Pembuatan Mi Sagu (Metroxylon Sagu) Kering. Jurnal Agroindustri Halal, 3. https://doi.org/10.30997/jah.v3i1.691
Gayo, Z., Lucida, H., & Zaini, E. (2020). Solid dispersion of quercetin-PVP K-30 and its effects on the antioxidant activity. Jurnal Ilmiah Farmasi, 16, 144–154. https://doi.org/10.20885/jif.vol16.iss2.art6
Gozali, D., Wardhana, Y, W., & Shofa. (2015). Formulasi dan Evaluasi Tablet Dispersi Padat Kalsium Atorvastatin. Pharmascience, 2(2), 63–70. http://dx.doi.org/10.20527/jps.v2i2.5824
Hartesi, B., Sutrisno, D., Chairani, S., Ariska, P. (2020). Formulasi Tablet Asetosal Menggunakan Metode Kempa Langsung Dengan Bahan Pengisi Pati Kentang Pregelatinasi. Journal of Healthcare Technology and Medicine, 6(1), 2615–109. https://doi.org/10.24198/mfarmasetika.v8i1.42081
Huang, B. Bin, Liu, D. X., Liu, D. K., & Wu, G. (2019). Application of Solid Dispersion Technique to Improve Solubility and Sustain Release of Emamectin Benzoate. Molecules (Basel, Switzerland), 24(23). https://doi.org/10.3390/molecules24234315
Imtihani, H. N., Thalib, F. A., & Permatasari, S. N. (2021). Formulation and Evaluation of Solid Dispersion Chitosan Tablet From Whiteleg Shrimp (Litopenaeus Vannamei) Using PVP K-30 as A Carriers. Borneo Journal of Pharmacy, 4(1), 16–21. https://doi.org/10.33084/bjop.v4i1.1557
Indra, I., Fauzi, A., & Aryani, R. (2019). Karakterisasi dan Uji Disolusi Aspirin Hasil Rekristalisasi Penguap Pelarut. Jurnal Sains Farmasi & Klinis, 6(2), 164. https://doi.org/10.25077/jsfk.6.2.164-170.2019
Kemenkes, R. (2020). Farmakope Indonesia Edisi VI. Kementrian Kesehatan Republik Indonesia.
Khasanah, K., Nawangsari, D., & Kusuma, I. Y. (2022). Dispersi Padat Asetosal Menggunakan Polivinil Pirolidon (PVP) K-30 Dalam Sediaan Tablet Dengan Metode Kempa Langsung. Indonesian Journal of Chemical Research. 10(3), 183-194. https://doi.org/10.30598//ijcr.2023.10-kha
Kumala, A. P. (2016). Kecepatan Pelarutan Piroksikam Hasil Pembentukan Dispersi Padat Dengan PEG 4000 Dan PEG 6000. Akfarindo, 1(1), 10–18. https://doi.org/10.37089/jofar.v0i0.2
Kuncoro, B., Zaky, M., & lestari, I. (2015). Formulasi dan Evaluasi Fisik Sediaan Fast Dissolving Tablet Amlodipine Besylate Menggunakan Sodium Starch Glycolate sebagai Bahan Penghancur. Jurnal Farmagazine, 2(2), 30–38. https://doi.org/10.47653/farm.v2i2.19
Nawangsari, D. (2019). Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 11(02), 37–42. https://doi.org/10.35960/vm.v11i02.464
Ninik, Y., Sugiyon., Astuti, W., & Faizatul, M. (2014). Perbandingan Disolusi Asam Mefenamat Dalam Sistem Dispersi Padat Dengan PEG 6000 Dan PVP. Jurnal Ilmu Farmasi Dan Farmasi Klinik, 1–6. https://doi.org/10.31942/jiffk.v11i1.1282
Noval, N., & Rosyifa, R. (2021). Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30. Jurnal Surya Medika, 6, 94–101. https://doi.org/10.33084/jsm.v6i2.2125
Rukmawati, Y. E. A., Hartini, S., & Cahyanti, M. N. (2017). Isoterm Sorpsi Air Pada Tepung Ubi Jalar Terfermentasi Dengan Angkak. Jurnal Kimia Valensi, 3(1), 71–78. https://doi.org/10.15408/jkv.v3i1.4814
Rustiani, E., Widayanti, K., & Zaddana, C. (2022). Formulasi Tablet Kunyah Kombinasi Ekstrak Daun Kelor dan Katekin Gambir dengan Perbedaan Jenis Pengikat. Jurnal Farmagazine, 9(1), 63–70. https://doi.org/10.47653/farm.v9i1.578
Sudrajat, L. H. (2018). Pengaruh osmoconditioning menggunakan Polyethilene Glycol (PEG) 6000 terhadap viabilitas benih pepaya gunung (Carica pubescens Lenne & K. Koch) [Undergraduate thesis] Universitas Islam Negeri Maulana Malik Ibrahim Malang. http://etheses.uin-malang.ac.id/id/eprint/13983
Susanti, E. (2014). Pengaruh osmoconditioning dengan PEG (Polyethylene glycol) 6000 terhadap viabilitas benih kenaf (Hibiscus cannabinus L.) [Undergraduate thesis] Universitas Islam Negeri Maulana Malik Ibrahim. http://etheses.uin-malang.ac.id/id/eprint/458
Swarbrick, J. (2006). “Solid Dispersion” In : Encyclopedia of Pharmaceutical Technology: Volume 6 (3rd ed.) (3rd ed.). CRC Press. https://doi.org/10.1201/b19309
Tekko, I. A. (2019). Polyethylene Glycol-Based Solid Dispersions to Enhance Eprosartan Mesylate Dissolution and Bioavailability. Archives of Pharmacy & Pharmacology Research, 2(3), 1–11. https://doi.org/10.33552/appr.2019.02.000537
Tran, P., Pyo, Y.-C., Kim, D.-H., Lee, S.-E., Kim, J.-K., & Park, J.-S. (2019). Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs. Pharmaceutics, 11(3). https://doi.org/10.3390/pharmaceutics11030132
Usman, M. R., Nabila, R., & Hakiki, L. N. (2020). Ekstraksi Kalsium dari Cangkang Kerang Hijau (Perna viridis L.) dan Kerang Batik (Paphia undulata B.) dengan Metode Kalsinasi sebagai Sediaan Effervescent. Indo. J. Chem. Res., 8(2), 101–107. https://doi.org/10.30598//ijcr.2020.8-mru